منابع مشابه
Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity.
OBJECTIVE To analyze a cluster of 30 industrial coworkers with Parkinson's disease and parkinsonism subjected to long-term (8-33 years) chronic exposure to trichloroethylene. METHODS Neurological evaluations were conducted on the 30 coworkers, including a general physical and neurological examination and the Unified Parkinson's Disease Rating Scale. In addition, fine motor speed was quantifie...
متن کاملSyndromic parkinsonism and dementia associated with OPA 1 missense mutations
OBJECTIVE Mounting evidence links neurodegenerative disorders such as Parkinson disease and Alzheimer disease with mitochondrial dysfunction, and recent emphasis has focused on mitochondrial dynamics and quality control. Mitochondrial dynamics and mtDNA maintenance is another link recently emerged, implicating mutations in the mitochondrial fusion genes OPA1 and MFN2 in the pathogenesis of mult...
متن کاملLETTER TOTHE EDITOR Parkinsonism in GTP cyclohydrolase 1 mutation carriers
Sir, We read with great interest the article by Mencacci and colleagues (2014) reporting a significantly higher frequency of GTP cyclohydrolase 1 (GCH1) variants in patients with Parkinson’s disease compared to controls. Whole-exome sequencing of a large case-control cohort showed that rare GCH1 coding variants are associated with a 7-fold increased risk of Parkinson’s disease. Heterozygous los...
متن کاملSymptomatic Parkinsonism.
Parkinson's disease, 'paralysis agitans', is characterized by a number of abnormalities. A similar clinical picture may be symptomatic of other disturbances: these are briefly described and the differential diagnosis is discussed.
متن کاملParkinsonism--neuropathology.
for willed movements only, but subsequently also for following movements and the upward movement of the eyeballs which occurs on closing the lids. At a later stage, lateral conjugate gaze is also affected, the loss again first involving voluntary movements and at a later stage reflexly induced or following movements. Tremor is not a feature of this condition, which is unlikely to be missed if o...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1972
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.61.1126